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Old Nov 13, 2025, 04:58 PM
Freefalling26 Freefalling26 is offline
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Hello,
I’ve recently started the ketamine spray for TRD treatment resistant depression. I started to notice slight changes at first and now after the 9th treatment I don’t notice too much. My doctor decided to add another antidepressant on top of it. I’m praying it will help. I’ve been on 100s of meds over 20 years or so with various diagnosis and never found any to be very helpful.
Searching for connection, purpose, and meaning in my life….

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Old Nov 13, 2025, 06:34 PM
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CANDC CANDC is offline
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Welcome to MSF @Freefalling26 sorry to hear you are not experiencing improvement.

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  #3  
Old Nov 13, 2025, 07:31 PM
TheGal TheGal is offline
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Quote:
Originally Posted by Freefalling26 View Post
Searching for connection, purpose, and meaning in my life….
This resonates with me. I have TRD, too, and with psychotic features, plus anxiety.

Currently taking 3 antidepressants and even though I tried TMS (transcranial magnetic stimulation) it did not work for me.

What has potential, I'm finding is somatic healing techniques, which you can look into... such as EFT Tapping, (there's also EMDR), also playing with my cat. Meditation, too. And reading to myself out loud, as I find I have trouble reading/concentrating otherwise... sometimes singing along to songs. And connecting to other people who understand and care. If you are open to massage therapy or osteopathy and can afford it, then that might be something to look into as well.

Also many people mention the importance of exercise, but sometimes we're too depressed to do it or engage in self-care.

This is a good video by PESI (they have other good YouTube videos, too) for EFT Tapping.

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Old Yesterday, 03:08 PM
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eskielover eskielover is offline
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For me, my depression was treatment resistent because it was from a situation that occured & then the situation I had been living in for 33 years. Interesting because the depression went away as soon as I got out of the situation along with the anxiety it caused. All enough to actually cause it to be considered permanent disability. Therapy helped me process what I had gone through once I was out & have been well every since. Meds only caused me bad side effects.

Depression has many different causes depending on each individual. None of my mental health providers ever considered situational depression & I didn't for a long time because I had lived that way for so long it had become "normal". Best change I ever made in my life was to leave
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